With the appointment of Prof. Dr. Jürgen Berger (“Mathematics in Medicine") and Prof. Dr. Karl-Heinz Höhne ("Medical Informatics") in the year 1978, the Institute for Mathematics and Data Processing in Medicine was founded.

At the beginning of 2003 the Department of Mathematics in Medicine was converted into an independent Institute for Medical Biometry and Epidemiology (IMBE), which became a part of the newly established Center for Experimental Medicine.

Prof. Dr. Karl Wegscheider was Director of the institute from 2007 till 2016. He has continued to work at the institute ever since.

Prof. Dr. Heiko Becher accepted the invitation of the University medical-center Hamburg-Eppendorf to become Professor of Epidemiology in 2014. He was head of the department for epidemiology at our institute. He was director of the institute from April 2016 to September 2022.

From January till June 2017, Prof. Dr. Geraldine Rauch was Deputy Director and Head of Biometry at our institute.

Prof. Dr. Antonia Zapf has been Head of the Department of Biometry at the IMBE since April 1, 2018. From April 2018 to September 2022 she held the position of deputy director of the institute. Since October 2022 she is the director of the institute.

Since May 24, 2023, Prof. Dr. Malte Kohns Vasconcelos, MD, is the Head of the Department of Epidemiology.