Radiotherapy for Recurrent Medulloblastoma in Children and Adolescents: Survival after Re-Irradiation and First-Time Irradiation
Adolph J, Fleischhack G, Tschirner S, Rink L, Dittes C, Mikasch R, Dammann P, Mynarek M, Obrecht-Sturm D, Rutkowski S, Bison B, Warmuth-Metz M, Pietsch T, Pfister S, Pajtler K, Milde T, Kortmann R, Dietzsch S, Timmermann B, Tippelt S
CANCERS. 2024;16(11):.

Integrated proteomics spotlight the proteasome as a therapeutic vulnerability in Embryonal Tumors with Multilayered Rosettes
Dottermusch M, Biabani A, Lempertz T, Schumann Y, Navolic J, Godbole S, Obrecht D, Frank S, Dorostkar M, Voß H, Schlüter H, Rutkowski S, Schüller U, Neumann J
NEURO-ONCOLOGY. 2024;26(5):935-949.

Risk factors for domain-specific neurocognitive outcome in pediatric survivors of a brain tumor in the posterior fossa - Results of the HIT 2000 trial
Mynarek M, Rossius A, Guiard A, Ottensmeier H, von Hoff K, Obrecht-Sturm D, Bußenius L, Friedrich C, von Bueren A, Gerber N, Traunwieser T, Kortmann R, Warmuth-Metz M, Bison B, Thomale U, Krauss J, Pietsch T, Clifford S, Pfister S, Sturm D, Sahm F, Tischler T, Rutkowski S
NEURO-ONCOLOGY. 2024 [Epub ahead of print].

Transcriptomic and epigenetic dissection of spinal ependymoma (SP-EPN) identifies clinically relevant subtypes enriched for tumors with and without NF2 mutation
Neyazi S, Yamazawa E, Hack K, Tanaka S, Nagae G, Kresbach C, Umeda T, Eckhardt A, Tatsuno K, Pohl L, Hana T, Bockmayr M, Kim P, Dorostkar M, Takami T, Obrecht D, Takai K, Suwala A, Komori T, Godbole S, Wefers A, Otani R, Neumann J, Higuchi F, Schweizer L, Nakanishi Y, Monoranu C, Takami H, Engertsberger L, Yamada K, Ruf V, Nomura M, Mohme T, Mukasa A, Herms J, Takayanagi S, Mynarek M, Matsuura R, Lamszus K, Ishii K, Kluwe L, Imai H, von Deimling A, Koike T, Benesch M, Kushihara Y, Snuderl M, Nambu S, Frank S, Omura T, Hagel C, Kugasawa K, Mautner V, Ichimura K, Rutkowski S, Aburatani H, Saito N, Schüller U
ACTA NEUROPATHOL. 2024;147(1):22.

Pineal anlage tumor: clinical and diagnostic features, and rationales for treatment
Obrecht-Sturm D, Pfaff E, Mynarek M, Bison B, Rodehüser M, Becker M, Kietz S, Pfister S, Jones D, Sturm D, von Deimling A, Sahm F, Kortmann R, Schwarz R, Pietsch T, Fleischhack G, Rutkowski S
J NEURO-ONCOL. 2024;166(2):359-368.

Medulloblastoma in children with Fanconi anemia: Association with FA-D1/FA-N, SHH type and poor survival independent of treatment strategies
Sönksen M, Obrecht-Sturm D, Hernáiz Driever P, Sauerbrey A, Graf N, Kontny U, Reimann C, Langhein M, Kordes U, Schwarz R, Obser T, Boschann F, Schüller U, Altendorf L, Goschzik T, Pietsch T, Mynarek M, Rutkowski S
NEURO-ONCOLOGY. 2024 [Epub ahead of print].

Outcomes of Infants and Young Children With Relapsed Medulloblastoma After Initial Craniospinal Irradiation-Sparing Approaches: An International Cohort Study
Erker C, Mynarek M, Bailey S, Mazewski C, Baroni L, Massimino M, Hukin J, Aguilera D, Cappellano A, Ramaswamy V, Lassaletta A, Perreault S, Kline C, Rajagopal R, Michaiel G, Zapotocky M, Santa-Maria Lopez V, La Madrid A, Cacciotti C, Sandler E, Hoffman L, Klawinski D, Khan S, Salloum R, Hoppmann A, Larouche V, Dorris K, Toledano H, Gilheeney S, Abdelbaki M, Wilson B, Tsang D, Knipstein J, Oren M, Shah S, Murray J, Ginn K, Wang Z, Fleischhack G, Obrecht D, Tonn S, Harrod V, Matheson K, Crooks B, Strother D, Cohen K, Hansford J, Mueller S, Margol A, Gajjar A, Dhall G, Finlay J, Northcott P, Rutkowski S, Clifford S, Robinson G, Bouffet E, Lafay-Cousin L
J CLIN ONCOL. 2023;41(10):1921-1932.

Clinical outcome of pediatric medulloblastoma patients with Li-Fraumeni syndrome
Kolodziejczak A, Guerrini-Rousseau L, Planchon J, Ecker J, Selt F, Mynarek M, Obrecht D, Sill M, Autry R, Zhao E, Hirsch S, Amouyal E, Dufour C, Ayrault O, Torrejon J, Waszak S, Ramaswamy V, Pentikainen V, Demir H, Clifford S, Schwalbe E, Massimi L, Snuderl M, Galbraith K, Karajannis M, Hill K, Li B, Walsh M, White C, Redmond S, Loizos L, Jakob M, Kordes U, Schmid I, Hauer J, Blattmann C, Filippidou M, Piccolo G, Scheurlen W, Farrag A, Grund K, Sutter C, Pietsch T, Frank S, Schewe D, Malkin D, Ben-Arush M, Sehested A, Wong T, Wu K, Liu Y, Carceller F, Mueller S, Stoller S, Taylor M, Tabori U, Bouffet E, Kool M, Sahm F, von Deimling A, Korshunov A, von Hoff K, Kratz C, Sturm D, Jones D, Rutkowski S, van Tilburg C, Witt O, Bougeard G, Pajtler K, Pfister S, Bourdeaut F, Milde T
NEURO-ONCOLOGY. 2023;25(12):2273-2286.

Identification of low and very high-risk patients with non-WNT/non-SHH medulloblastoma by improved clinico-molecular stratification of the HIT2000 and I-HIT-MED cohorts
Mynarek M, Obrecht D, Sill M, Sturm D, Kloth-Stachnau K, Selt F, Ecker J, von Hoff K, Juhnke B, Goschzik T, Pietsch T, Bockmayr M, Kool M, von Deimling A, Witt O, Schüller U, Benesch M, Gerber N, Sahm F, Jones D, Korshunov A, Pfister S, Rutkowski S, Milde T
ACTA NEUROPATHOL. 2023;145(1):97-112.

A multi-institutional retrospective pooled outcome analysis of molecularly annotated pediatric supratentorial ZFTA-fused ependymoma
Ng C, Obrecht D, Wells O, Zapotocky M, Sumerauer D, Coltin H, Khuong-Quang D, Eisenstat D, Kinross K, White C, Algar E, Luck A, Witt H, Schüller U, Mynarek M, Pietsch T, Gerber N, Benesch M, Warmuth-Metz M, Kortmann R, Bison B, Taylor M, Rutkowski S, Pfister S, Jones D, Gottardo N, von Hoff K, Pajtler K, Ramaswamy V, Hansford J
NEURO-ONCOL ADV. 2023;5(1):vdad057.

Kinder und Jugendliche mit intrakraniellem Ependymom – Empfehlungen der HIT-MED-Studiengruppe der GPOH zur Erstlinientherapie
Obrecht D, Mynarek M, Stickan-Verfürth M, Bison B, Schüller U, Pajtler K, Hagel C, Thomale U, Fleischhack G, Timmermann B, Rutkowski S
KLIN PADIATR. 2023;235(3):167-177.

Risk prediction in early childhood sonic hedgehog medulloblastoma treated with radiation-avoiding chemotherapy
Tonn S, Korshunov A, Obrecht D, Sill M, Spohn M, von Hoff K, Milde T, Pietsch T, Goschzik T, Bison B, Juhnke B, Struve N, Sturm D, Sahm F, Bockmayr M, Friedrich C, von Bueren A, Gerber N, Benesch M, Jones D, Kool M, Wefers A, Schüller U, Pfister S, Rutkowski S, Mynarek M
NEURO-ONCOLOGY. 2023;25(8):1518-1529.

Comprehensive profiling of myxopapillary ependymomas identifies a distinct molecular subtype with relapsing disease
Bockmayr M, Harnisch K, Pohl L, Schweizer L, Mohme T, Körner M, Alawi M, Suwala A, Dorostkar M, Monoranu C, Hasselblatt M, Wefers A, Capper D, Hench J, Frank S, Richardson T, Tran I, Liu E, Snuderl M, Engertsberger L, Benesch M, von Deimling A, Obrecht D, Mynarek M, Rutkowski S, Glatzel M, Neumann J, Schüller U
NEURO-ONCOLOGY. 2022;24(10):1689-1699.

Types of deviation and review criteria in pretreatment central quality control of tumor bed boost in medulloblastoma-an analysis of the German Radiotherapy Quality Control Panel in the SIOP PNET5 MB trial
Dietzsch S, Braesigk A, Seidel C, Remmele J, Kitzing R, Schlender T, Mynarek M, Geismar D, Jablonska K, Schwarz R, Pazos M, Weber D, Frick S, Gurtner K, Matuschek C, Harrabi S, Glück A, Lewitzki V, Dieckmann K, Benesch M, Gerber N, Obrecht D, Rutkowski S, Timmermann B, Kortmann R
STRAHLENTHER ONKOL. 2022;198(3):282-290.

Local and Systemic Therapy of Recurrent Medulloblastomas in Children and Adolescents: Results of the P-HIT-REZ 2005 Study
Gaab C, Adolph J, Tippelt S, Mikasch R, Obrecht D, Mynarek M, Rutkowski S, Pfister S, Milde T, Witt O, Bison B, Warmuth-Metz M, Kortmann R, Dietzsch S, Pietsch T, Timmermann B, Sträter R, Bode U, Faldum A, Kwiecien R, Fleischhack G
CANCERS. 2022;14(3):.

Genetic alterations of TP53 and OTX2 indicate increased risk of relapse in WNT medulloblastomas
Goschzik T, Mynarek M, Doerner E, Schenk A, Spier I, Warmuth-Metz M, Bison B, Obrecht D, Struve N, Kortmann R, Schmid M, Aretz S, Rutkowski S, Pietsch T
ACTA NEUROPATHOL. 2022;144(6):1143-1156.

Refining M1 stage in medulloblastoma: criteria for cerebrospinal fluid cytology and implications for improved risk stratification from the HIT-2000 trial
Hagel C, Sloman V, Mynarek M, Petrasch K, Obrecht D, Kühl J, Deinlein F, Schmid R, von Bueren A, Friedrich C, Juhnke B, Gerber N, Kwiecien R, Girschick H, Höller A, Zapf A, von Hoff K, Rutkowski S
EUR J CANCER. 2022;164:30-38.

Clinical and molecular characterization of isolated M1 disease in pediatric medulloblastoma: experience from the German HIT-MED studies
Obrecht D, Mynarek M, Hagel C, Kwiecien R, Spohn M, Bockmayr M, Bison B, Pfister S, Jones D, Sturm D, von Deimling A, Sahm F, von Hoff K, Juhnke B, Benesch M, Gerber N, Friedrich C, von Bueren A, Kortmann R, Schwarz R, Pietsch T, Fleischhack G, Schüller U, Rutkowski S
J NEURO-ONCOL. 2022;157(1):37-48.

Local and Systemic Therapy of Recurrent Ependymoma in Children and Adolescents: Short- and Long-term Results of the E-HIT-REZ 2005 Study
Adolph J, Fleischhack G, Mikasch R, Zeller J, Warmuth-Metz M, Bison B, Mynarek M, Rutkowski S, Schüller U, von Hoff K, Obrecht D, Pietsch T, Pfister S, Pajtler K, Witt O, Witt H, Kortmann R, Timmermann B, Krauß J, Frühwald M, Faldum A, Kwiecien R, Bode U, Tippelt S
NEURO-ONCOLOGY. 2021;23(6):1012-1023.

Defining the Spectrum, Treatment and Outcome of Patients With Genetically Confirmed Gorlin Syndrome From the HIT-MED Cohort
Kloth K, Obrecht D, Sturm D, Pietsch T, Warmuth-Metz M, Bison B, Mynarek M, Rutkowski S
FRONT ONCOL. 2021;11:.

Nonmetastatic Medulloblastoma of Early Childhood: Results From the Prospective Clinical Trial HIT-2000 and An Extended Validation Cohort
Mynarek M, von Hoff K, Pietsch T, Ottensmeier H, Warmuth-Metz M, Bison B, Pfister S, Korshunov A, Sharma T, Jaeger N, Ryzhova M, Zheludkova O, Golanov A, Rushing E, Hasselblatt M, Koch A, Schüller U, von Deimling A, Sahm F, Sill M, Riemenschneider M, Dohmen H, Monoranu C, Sommer C, Staszewski O, Mawrin C, Schittenhelm J, Brück W, Filipski K, Hartmann C, Meinhardt M, Pietschmann K, Haberler C, Slavc I, Gerber N, Grotzer M, Benesch M, Schlegel P, Deinlein F, von Bueren A, Friedrich C, Juhnke B, Obrecht D, Fleischhack G, Kwiecien R, Faldum A, Kortmann R, Kool M, Rutkowski S
J CLIN ONCOL. 2020;38(18):2028-2040.

Molecular characterization of histopathological ependymoma variants
Neumann J, Spohn M, Obrecht D, Mynarek M, Thomas C, Hasselblatt M, Dorostkar M, Wefers A, Frank S, Monoranu C, Koch A, Witt H, Kool M, Pajtler K, Rutkowski S, Glatzel M, Schüller U
ACTA NEUROPATHOL. 2020;139(2):305-318.

Effect of patent ductus arteriosus and patent foramen ovale on left ventricular stroke volume measurement by electrical velocimetry in comparison to transthoracic echocardiography in neonates
Blohm M, Hartwich J, Obrecht D, Kersten J, Singer D
J CLIN MONIT COMPUT. 2017;31(3):589-598.

Long-Term Clinical Relevance of De Novo Donor-Specific Antibodies After Pediatric Liver Transplantation
Grabhorn E, Binder T, Obrecht D, Brinkert F, Lehnhardt A, Herden U, Peine S, Nashan B, Ganschow R, Briem-Richter A
TRANSPLANTATION. 2015;99(9):1876-1881.

Impedance cardiography (electrical velocimetry) and transthoracic echocardiography for non-invasive cardiac output monitoring in pediatric intensive care patients: a prospective single-center observational study
Blohm M, Obrecht D, Hartwich J, Müller G, Kersten J, Weil J, Singer D
CRIT CARE. 2014;18(6):603.

Effect of cerebral circulatory arrest on cerebral near-infrared spectroscopy in pediatric patients
Blohm M, Obrecht D, Hartwich J, Singer D
PEDIATR ANESTH. 2014;24(4):393-9.

Letzte Aktualisierung aus dem FIS: 02.11.2024 - 23:45 Uhr